CD274 and hamartoma: Therefore, inflammation-related changes in ENS function likely involve neurodegeneration and neuroplasticity responsible for the main complication in CD, in some studies considered to be hamartoma.[11–13] IHC for PD-L1 and SSTR2A supports the significance of new formed neural structures, long PD-L1 positive fibers parallel to the crypt and meshes consisting of neuronal fragments staining positive to SSTR2A, as exuberant repair processes secondary to chronic inflammation (Fig. 3).