In the initial biopsy diagnosis of Crohn, any other additional features[19,20] must be searched for, and will result extremely useful in distinguishing Crohn from other IBD or recent described CEAS (chronic enteropathy associated with the SLCO2A1 gene).[21] It has been suggested that the diagnosis of CD should be based on the presence of 2 major or at least 3 minor criteria, in the absence of granulomas. Here, SLCO2A1 is linked to Cowden disease.