In the combined CD4+ and CD8+ T cell depleted group, the rate of chronic CFT073 cystitis was 61%, vs. 40% in the isotype-treated group (Fig 6A), and CFT073 urine titers at 28 dpi were significantly elevated in the combined T cell-depleted mice relative to isotype-treated controls (Fig 6B). Here, CD8A is linked to chronic cystitis.