Lastly, analysis of the sequencing data from the entire TARGET discovery set of 117 high risk WT identified a single patient with TRIM28 mutation in an anaplastic, epithelial WT that also contained a mutation in TP53. This patient had the same conserved splice-site mutation found in PAKVET (g.chr19:59059081G>A), with 93% alternate reads in the tumor sample. Here, TRIM28 is linked to neoplasm.