Functional annotation using GSEA and MSigDB [40, 49, 54] for KEGG pathways demonstrated that the upregulated probesets were enriched in TP53 signaling and pathways involved in cancer as well as adherens junction while the downregulated ones were enriched in functions such as DNA replication, cell cycle, and DNA repair mechanisms (Fig 3A). The gene discussed is TP53; the disease is cancer.