VDAC1 and Alzheimer disease: High levels of VDAC1 were demonstrated in the dystrophic neurites of Aβ deposits in post-mortem brains of AD patients and in amyloid precursor protein (APP) transgenic mice, where Aβ-VDAC interactions are toxic to AD-affected neurons 97, 98, 289, 287, 289, 290, 291.