Since the anti-apoptotic proteins HK-I, HK-II, Bcl2 and Bcl-xL have been found to be expressed at high levels in many types of cancer 81, 253, 305, 306, 307, 308, 309, 310 and interact with VDAC1 1, 22, 23, 24, 25, 26, 27, 81, 82, 84, 118, 122, 124, 128, 220, 311, 312, the interaction of VDAC1with these proteins is proposed as an appropriate target to induce apoptosis. Here, HK1 is linked to cancer.