The therapeutic potential of a number of miRNAs able to regulate VDAC1 expression levels is clear in view of the observation that VDAC1 over-expression is associated with a variety of pathological conditions, including Alzheimer's disease (AD) 97, 98, 99, and cardiovascular diseases (CVDs) 100. The gene discussed is VDAC1; the disease is early-onset autosomal dominant Alzheimer disease.