IRF1 and infection: Finally, given its importance to the host response to infection, we examined the status of macrophage activation, and observed a good degree of concordance for M1-associated transcripts (as described in Figure 6 of41) between hamster and mouse (55% of genes, includingCcl2,Cxcl9,Cxcl10,Ifng,Irf1,Irf7,Irg1,Socs3,Stat1 and Ccr7).