Aiming to clarify the function of PLA2R1 in prostate cancer, we established two in vitro prostate cancer cell line models that include LNCaP cells with ectopically overexpressed PLA2R1 (LNCaP-PLA2R1) and PC3 cells with PLA2R1-knockdown (PC-3 KD), where wildtype PLA2R1 expression is increased relative to normal prostate epithelial cells (Figure 1). This evidence concerns the gene PLA2R1 and Familial prostate cancer.