The inability of receptors to bind GH and their failure in inducing GH signaling in cells, caused by the mutations seen in Laron syndrome patients, has been related to protection from age-related disease, as reported by Shevah and Laron (2007) and by Guevara-Aguirre et al. (2011) in a study of Ecuadorian subjects. This evidence concerns the gene GH1 and Laron syndrome.