For example, GH resistance of “Laron dwarf” GHR-/- mice is due to deletion of most of the fourth exon and part of the fourth intron of the Ghr gene (Coschigano et al., 2003), while Laron syndrome in different human cohorts is due to various deletions, splice variants, nonsense, missense, or frameshift mutations (Berg et al., 1993; Janecka et al., 2016). The gene discussed is GH1; the disease is Laron syndrome.