GHRHR and isolated congenital growth hormone deficiency: Interestingly, no GHRH gene mutations have been reported in humans, as opposed to GHRH receptor (GHRHR) gene mutations, which have emerged as a common cause of inherited autosomal recessive isolated GH deficiency (IGHD) also known as Dwarfism of Sindh (a province in Pakistan) (Alba and Salvatori, 2004b; Aguiar-Oliveira et al., 2010).