ATG5 and infection: Similarly, Atg5 or Atg7 deficiency in macrophages rescues mice from influenza induced pathology only after priming of adaptive immune responses (10 days post-infection), while components of the ULK1/Atg1 complex and the VPS34 PI3 kinase complex, Fip200 and Atg14, are also required for the influenza induced pathology during innate immunity at earlier timepoints (27).