Similarly, Atg5 or Atg7 deficiency in macrophages rescues mice from influenza induced pathology only after priming of adaptive immune responses (10 days post-infection), while components of the ULK1/Atg1 complex and the VPS34 PI3 kinase complex, Fip200 and Atg14, are also required for the influenza induced pathology during innate immunity at earlier timepoints (27). This evidence concerns the gene PIK3C3 and influenza.