It is known that glioma cells secrete soluble factors that contribute to the establishment of a pro-tumor microenvironment switching GAMs toward an anti-inflammatory phenotype (2, 32, 34); thus, considering that microglia cells do express CXCR6, we speculated that CXCL16 released by tumor cells might act as an effector in driving such microglia polarization. This evidence concerns the gene CXCL16 and neoplasm.