Since tumor micro-environment plays an important role in glioma progression, and considering the ability of CXCL16 to promote microglia anti-inflammatory phenotype in vitro, we decided to investigate the effect of CXCL16/CXCR6 signaling on tumor micro-environment in vivo: we therefore orthotopically implanted GL261 cells into the brain of wt and cxcr6ko mice. The gene discussed is CXCR6; the disease is glioma.