We report that neutralization of soluble CXCL16 in GCM results in a strong reduction in the expression of anti-inflammatory genes in microglia (arg-1, chil3, retnla, cd163), and in a significant increase of pro-inflammatory genes (nos2, il-1b, cd86, tnfa), compared to microglia cells exposed to control GCM, suggesting that soluble CXCL16 released by tumor cells promotes microglia pro-tumor phenotype. Here, CXCL16 is linked to neoplasm.