We analyzed the expression of CXCL16 and CXCR6 in human GBM tissues acutely (< 2 h) removed from patients, and in normal cerebral tissues (controls) derived from the temporal and frontal cortex of patients who died for heart failure: RT-qPCR analysis revealed a significant higher expression for cxcl16 and cxcr6 mRNAs in GBM, compared to controls (Figure 2A left panel) (p < 0.001 and p < 0.05, respectively; Student's t-test). This evidence concerns the gene CXCR6 and glioblastoma.