It is known that glioma cells secrete soluble factors that contribute to the establishment of a pro-tumor microenvironment switching GAMs toward an anti-inflammatory phenotype (2, 32, 34); thus, considering that microglia cells do express CXCR6, we speculated that CXCL16 released by tumor cells might act as an effector in driving such microglia polarization. The gene discussed is CXCL16; the disease is central nervous system cancer.