Moreover, since disruption of CXCL16 signaling counteracts glioma progression limiting cell proliferation and migration but also microglia pro-tumor polarization, a multi-target therapy including the use of a CXCR6 antagonist, together with drugs approved by Food and Drug Administration (FDA) and currently used to treat GBM patients (such as Temozolomide or checkpoint inhibitors that target programmed cell death protein 1,PD-1) could be potentially considered in the future. This evidence concerns the gene CXCR6 and glioblastoma.