In spite of the low expression level of cxcr6, we demonstrate that the human primary GBM cells do express CXCR6 protein (as revealed by flow cytometry analysis) and respond to CXCL16 stimulation, modulating migration, invasion, and proliferation, thus suggesting an important activity of CXCL16 in glioma cell biology also in humans. The gene discussed is CXCL16; the disease is central nervous system cancer.