We have previously shown that GL261/cd133+ cells grafted in mice resulted in a higher tumor volume compared to mice grafted with GL261 (43), we now report that within glioma, GL261/cd133+ cells do present a higher cxcr6 mRNA expression compared to GL261, thus suggesting that autocrine CXCL16 signaling plays also a role in cancer stem cells. Here, CXCL16 is linked to central nervous system cancer.