AKT1 and B-cell chronic lymphocytic leukemia: Several pathways are involved in the proliferation and survival of CLL cells, including the mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK), nuclear factor κB (NF-κB), Notch, Wnt, phosphatidylinositol-3-kinase/AKT (PI3K/AKT), and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways (89).