It also cross-talks with various other pathways; for instance, stimulation of NF-κB upregulates BFL-1 and B cell lymphoma-extra-large (BCL-XL) anti-apoptotic genes, which inhibit the apoptosis of CLL cells via PI3K/AKT signaling. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.