IL4 and B-cell chronic lymphocytic leukemia: CLL cells secrete IL-4, -10, and -13 (73) that endorse M2-like properties in macrophages and stimulate pro-survival responses through the secretion of IL-8 (74), CCL2, CXCL2, 12 (75, 76), and insulin-like growth factor-1 (IGF-1) (77).