In this study we included only the two SNPs (BDNF Val66Met and C270T polymorphisms), so additional BDNF gene polymorphisms should be included in future studies, such as those evaluated in healthy control subjects: BDNF rs12291063 polymorphism associated with BMI and obesity (104), BDNF rs10767664 polymorphism associated with BMI, weight, fat mass, waist circumference, LDL cholesterol and total cholesterol (105), or BDNF rs925946 polymorphism associated with BMI (98), or GWAS data. Here, BDNF is linked to obesity due to melanocortin 4 receptor deficiency.