DRD2 and alcohol abuse: In 1995, Lawford et al. administered bromocriptine or placebo to subjects with alcohol use disorder (AUD), in a double-blind study, they found that the most significant improvement in craving and anxiety occurred in the bromocriptine treated subjects with the Dopamine Receptor D2 (DRD2) A1 allele and attrition was highest in the placebo-treated A1 subjects (21).