Sullivan et al. focus on the role of aberrant dopaminergic signaling, interaction with dopamine transporter DAT, a cocaine target, and the dopamine D2 receptor in subjects and controls from the Miami Dade County Brain Bank splicing polymorphism rs2283265 of DRD2, encoding D2 receptors, was shown to confer risk (odds ratio ~3) of cocaine overdose/death. Here, DRD2 is linked to overdose.