While no difference in lesion size was observed, LDL-receptor knockout mice transplanted with bone marrow from Gdf15 deficient mice showed enhanced macrophage accumulation and features of atherosclerotic plaque destabilization, suggesting a protective role of GDF15 in advanced atherosclerosis and macrophage accumulation (Preusch et al., 2013). The gene discussed is GDF15; the disease is atherosclerosis.