GDF15 and Cachexia: These observations, initiated a considerable effort to develop therapeutics targeted to the GDF15 system including anti-GDF15 antibodies proposed as a novel therapeutic strategy to treat cancer – induced cachexia (Gyuris, Lerner, Lin, WO2016/049470), the effort to deorphanize the GDF15 receptor (discussed section “Conclusion”) and the development of novel GDF15 analogs for the treatment of obesity and diabetes (Xiong et al., 2017).