PPARG and myeloid leukemia: PPARγ agonists (e.g., PGZ) have also been suggested as potential modulators in myeloid leukemia by activating the transcriptional activity of target genes that control apoptosis and differentiation (Konopleva et al., 2004; Saiki et al., 2006) as well as by downregulation of the STAT5-driven quiescence of the leukemic stem cell pool (Prost et al., 2015).