FLT3 and acute myeloid leukemia: Since most AML samples responding to ATRA/AZA/PGZ treatment were positive for FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD), we analyzed the effects of the multikinase inhibitor midostaurin (MIDO) as single agent as well as in combination with ATRA, AZA, and PGZ on FLT3-ITD+ AML cell lines MV4-11 (Figure 5A) and MOLM-13 (Figure 5B).