SLC6A2 and Alzheimer disease: Studies of post-mortem tissue have demonstrated a significant reduction of total LC cell number in MCI and AD as well as decrease in norepinephrine transporter (NET), responsible for the reuptake of NA, in several brain areas of AD patients including the cerebellum (Tejani-Butt et al., 1993; Gulyás et al., 2010; Kelly et al., 2017).