APP and Alzheimer disease: According to different studies, Aβ1–42 does not affect the PF-PC basal synaptic transmission (paired-pulse facilitation and/or input-output relationship) whether it is autonomously produced in AD mouse models, including APP/PS1, or administered to cerebellar slices of WT mice, at a concentration of 500 nM (Hoxha et al., 2012; Kuwabara et al., 2014; Russo et al., 2018).