In the last decades, mouse models of AD expressing mutant human APP, sometimes together with mutant presenilins, have been widely used for investigating the AD pathophysiology and to establish new therapeutic strategies (Ashe and Zahs, 2010; Puzzo et al., 2015; Drummond and Wisniewski, 2017; Sasaguri et al., 2017). The gene discussed is APP; the disease is Alzheimer disease.