In fact, the expression of glutamate transporter 1 (GLT-1) and glutamate–aspartate transporter (GLAST) prevents glutamate-derived excitotoxicity during neuronal regular synaptic transmission (Danbolt, 2001); and under glutamatergic over-excitation, such as that observed in conditions like epilepsy or brain trauma (Tanaka et al., 1997; Goodrich et al., 2013). This evidence concerns the gene SLC1A2 and epilepsy.