Age (Uribe et al., 2016), gender (Luders et al., 2006), disease duration (Madhyastha et al., 2015) are associated with the cortical thickness, which might reflect a mixed pathologic features, such as neuronal density (La Fougere et al., 2011), cerebral perfusion (Nobili et al., 2011; Madhyastha et al., 2015), degenerative pathologies including tau, α-synuclein in PD patients (Ye et al., 2017). The gene discussed is MAPT; the disease is Parkinson disease.