Leukocytes such as dendritic cells can release IL-22BP but the effects of higher decoy receptor expression, and hence lower levels of available IL-22, appear to vary according to the disease condition, with decreased disease severity in an animal model of psoriasis (Martin et al., 2017) and greater hepatic fibrosis in human schistosomiasis patients (Sertorio et al., 2015). The gene discussed is IL22; the disease is psoriasis.