GRM4 and ischemia: We tested the active and inactive form of this molecule to investigate the mGlu4 – mediated inhibition of PC excitatory postsynaptic currents (EPSCs) evoked by electrical stimulation of PFs (PF–EPSCs) during concomitant activation of these receptors by the group III mGlu receptor orthosteric agonist, L-AP4 (10 μM) or during the early phase of simulated ischemia.