Moreover, Panx1-KO mice treated with kainate exhibited less severe seizures and lower extracellular concentrations of ATP compared to kainate-treated WT-mice, strongly suggesting an important role for Panx1 HCs in mediating ATP release in epilepsy (Dubyak, 2009; Santiago et al., 2011; Mylvaganam et al., 2014). Here, PANX1 is linked to epilepsy.