According with previous descriptions made in our epilepsy animal model (Morales et al., 2014), astrogliosis was confirmed in all hippocampal formation of kindled rats, with a great number of GFAP+ astrocytes (KD 20.3 ± 1.0 cells/mm2, n = 11 slices; CT 13.9 ± 0.7 cells/mm2, n = 11 slices; p < 0.001), which showed thicker, elongated and more sinuous processes located in both stratum radiatum and oriens, as well as in pyramidal layers. This evidence concerns the gene GFAP and epilepsy.