Remarkably, several studies show that insulin signaling is impaired in the brains of AD patients and AD experimental models (Boyt et al., 2000; Craft et al., 2003; Steen et al., 2005; Bomfim et al., 2012; Hiltunen et al., 2012; Talbot et al., 2012). This evidence concerns the gene INS and Alzheimer disease.