During the past decades, mounting studies correlate the alterations in IR/IGF-R signaling pathways and AD (Boyt et al., 2000; Craft et al., 2003; Bomfim et al., 2012; Hiltunen et al., 2012; Talbot et al., 2012; Pitt et al., 2017). This evidence concerns the gene INSR and Alzheimer disease.