Conversely, targeting microglia-mediated conversion of astrocytes into A1 type with NLYP01, a novel glucagon like peptide 1 receptor (GLP1R) agonist, increases lifespan and reverses the loss of dopaminergic neurons, and behavioral deficits in mouse models of Parkinson's disease (Yun et al., 2018). Here, GLP1R is linked to Parkinson disease.