We further confirmed these observations by showing that two representative wt-TP53 neuroblastoma cells (IMR-32 and CHLA-15) treated with quarfloxin or CX-5461 had increased expression of the 17/19 kDa cleaved-Caspase-3 (c-Casp-3) and induction of p21 protein and mRNA expression (Fig. 3b, Supplementary Figure 6). The gene discussed is CASP3; the disease is neuroblastoma.