Previously, it was reported that Batf3-deficient mice displayed similar survival rates to Erdman strain of Mtb infection compared to wild-type animals.5 In contrast to Batf3, Batf2 deletion in mice controlled lung pathology and ill-defined granuloma formation that leads to an aggressive TB pathology/damage, which drives the disease progression and subsequent death of the host following HN878 infection. Here, BATF3 is linked to tuberculosis.