BATF2 and tuberculosis: Indeed, granulocyte depletion significantly extended the survival of Mtb-infected mice22 and TB susceptibility is determined by the increased accumulation of a permissive monocyte/macrophage population in the lung.23 The mechanisms of increased resistance of Batf2−/− mice could be explained by reduced recruitment of inflammatory macrophages in the lungs, thereby limiting the numbers and availability of permissive macrophages.