In a genome-wide transcriptomics analysis, we previously reported that Batf2 is highly induced in Mtb-infected and IFN-γ activated macrophages (M1) in vitro.4 Lung alveolar macrophages are the first host cells that become infected by Mtb.9 Thus, we first determined Batf2 mRNA expression in flow-sorted alveolar macrophages (CD11c+Siglec-F+autofluorescencehigh) from HN878 Mtb-infected WT and Batf2−/− mice at 3 weeks post-infection. Here, BATF2 is linked to infection.