CD4 and schistosomiasis: Of note, the expansion of small intestinal CD8+ dendritic cells primarily associated with the deleterious effect of Batf2 deficiency during acute schistosomiasis, which does suggests a role for small intestinal CD8+ dendritic cells – and most likely the resulting of elevated CD4+ and CD8+ T cell responses – in the increased small intestinal fibrogranulomatous inflammation reported.