In conclusion, the ACE2 variant rs2074192 was associated with EH and EHwith CAS ≥ 50%, while three ACE2 variants (rs4240157, rs4646155, and rs4830542) wereassociated with EH- and hypertension-related AF and left atrial remodeling.Specially, our data show for the first time that the ACE2 SNP rs4830542 had thoseeffects, while rs2048683 did not, suggesting that the ACE2 SNP rs4830542 may be anovel genetic susceptibility marker for EH (especially in females) and EH-relatedcardiovascular events. The gene discussed is ACE2; the disease is Hypertension.