In cell-based assays, CL27c readily reduced Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells15 stimulated with anti-IgM antibodies (Fig. 1a and Supplementary Fig. 3a), as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a (Fig. 1a and Supplementary Fig. 3b, c). Here, CD40LG is linked to B-cell chronic lymphocytic leukemia.