SPECC1L and acne: Colocalisation further implicated genes with established roles in skin biology at several other newly identified acne susceptibility loci: LGR6 at 1q32.1, which encodes a glycoprotein hormone receptor that is observed to be strongly expressed by cells in the stem cell niche within the pilosebaceous unit in mice;19FGF2 at 4q28.1, which has established roles in wound healing and scarring, and SPECC1L at 22q11.23, which has previously been identified as the site of rare pathogenic mutations in forms of oblique facial clefting (OMIM: 600251).