GATA3 and coinfection: In particular, HIV coinfection resulted in a significant shift of the M. tuberculosis-specific cytokine profile from a mixed Th1/Th2/Th17 cytokine profile associated with increased Gata-3 and RORγt and reduced T-bethigh expression observed in individuals with LTBI or PTB to a Th1-restricted cytokine profile associated with increased T-bethigh and reduced Gata-3 or RORγt expression observed in individuals with HIV/LTBI or HIV/PTB.