Since HIV infection significantly influenced Th1, Th2, and Th17 cytokine production/secretion, we then determined whether HIV infection was associated with changes in the expression of Th1-, Th2-, and Th17-specific cell lineage transcription factors T-bet, Gata-3, and RORγt, respectively (22, –, 24). Here, GATA3 is linked to HIV infectious disease.