The fact that the cytokine profiles of M. tuberculosis-specific CD8 T-cell responses in PTB versus HIV/PTB differed significantly provides additional evidence that HIV infection may substantially influence M. tuberculosis-specific T-cell responses during active TB disease and echoes the recent findings from Chiacchio et al. that showed that M. tuberculosis-specific CD8 T cells from M. tuberculosis/HIV-coinfected individuals are more monofunctional (42). This evidence concerns the gene CD8A and HIV infectious disease.