However, neither the proportion of IL-2-producing M. tuberculosis-specific CD4 T cells nor the level of PD-1 on M. tuberculosis-specific CD4 T cells of M. tuberculosis/HIV-coinfected individuals correlated with HIV viral load, suggesting that the influence of HIV infection on M. tuberculosis-specific CD4 T-cell cytokine profile and phenotype might be indirect. This evidence concerns the gene CD4 and HIV infectious disease.