EZH2 and malignant colon neoplasm: To further demonstrate that EZH2 and HDACs (specifically, HDAC6) could influence the migration of colon cancer cells, Snail2-overexpressing cells were treated with GSK343, TSA, or Tubastatin A. As shown in Fig. 4g, compared with control cells (SW480-N), the migration of these cells significantly increased.