Here we focus on current AD therapeutic strategies which comprise of mechanism-based approaches including amyloid-beta (Aβ) clearance, tau protein deposits, apolipoprotein-E (ApoE) function, neuroprotection and neuroinflammation, as well as non-mechanism based approaches including symptomatic cognitive stimulation, AD prevention, lifestyle modifications and risk factor management including non-pharmacological interventions (Table 1: a summary list of therapeutic strategies discussed in this paper). The gene discussed is APOE; the disease is Alzheimer disease.