Finally, Tspan8 and CD151 assist angiogenic receptor expression in MCA tumor cells and TEX, VEGFR2 [127, 128] being reduced in Tspan8ko and CD151ko, VEGFR3 [41, 45, 47, 48] and EphA4 [124] being more strongly reduced in Tspan8ko- and dbko-MCA. This evidence concerns the gene EPHA4 and neoplasm.