Impaired settlement of Tspan8ko- and CD151ko-MCA in the autochthonous BM, partly restored in the wt-host, suggested a contribution of sExo/TEX-Tspan8 and -CD151 to tumor cell settlement in the BM [103, 104] and to deviation of hematopoiesis [53, 105]. Here, CD151 is linked to neoplasm.