Exploring a possible impact of host Exo and TEX Tspan8 and CD151 on tumor growth and progression required a criss-cross evaluation of the MCA wt, Tspan8ko and/or CD151ko tumors in the autochthonous and the syngeneic host differing in Tspan8 and/or CD151 competence. This evidence concerns the gene TSPAN8 and neoplasm.