MKI67 and neoplasm: Instead, tumour weights and sizes were markedly larger in the GRINA-OE group than in the control group 4 weeks later (P < 0.01) (Figs. 3I-3K) Immunofluorescence staining for Ki67 reaveled that tumor tissues in the control group showed higher positivity rate than those in the shRNA group (Fig. 3L).