Another type of Smac mimetic, BV6, can also elicit necroptosis depending on TNF-α and the activation of its downstream components of the necroptosis pathway, such as RIPK1, RIPK3 and MLKL, in AML cells, in which apoptosis is inhibited pharmacologically by the pan-caspase inhibitor zVAD-fmk or genetically by caspase-8 knockdown. The gene discussed is MLKL; the disease is acute myeloid leukemia.