Finally, in vivo experiments on nude mice comparing the vascularity development as well as other changes (VEGF intratumoral levels, tumor mass and Ki67 index) following s.c. inoculation of Scr, or MCF-7 ALDH1A1+ or MCF-7 ALDH1A1KD tumor cells, provided results comparable to those obtained in vitro. This evidence concerns the gene ALDH1A1 and neoplasm.