As shown in Fig. 2 (upper panel), the levels of total IL-18 were significantly lower in SMC (199.0 ± 67.8 pg/ml) compared to NHS (245.6 ± 96.0 pg/ml, p = 0.01) and MCI (264.8 ± 128.0 pg/ml, p = 0.019), but not AD (309.8 ± 324.3 pg/ml). The gene discussed is IL18; the disease is Alzheimer disease.