IL1R1 and Alzheimer disease: From the summary presented in Table 2, it is notable that many of the factors that are increased in AD are inflammation-inhibiting molecules: the IL-1 inhibitors IL-1Ra, sIL-1R1, and sIL-1R3, the IL-18 inhibitor IL-18BP, and the IL-33 inhibitors sIL-1R4 and sIL-1R3.