IL1R2 and Alzheimer disease: In the case of sIL-1R2, the classical soluble decoy receptor, its levels were significantly higher in MCI (7286.5 ± 2599.5 pg/ml) compared to other groups (3715.6 ± 2004.2 pg/ml in NHS, 2754.8 ± 1113.1 pg/ml in SMC, and 3603.9 ± 1820.9 pg/ml in AD; p < 0.001) (Fig. 1, lower left).