IL18BP and Alzheimer disease: Regarding IL-18BP (Fig. 2, centre panel), it is notable that the levels of the inhibitor were significantly lower in both SMC (4512.7 ± 2387.7 pg/ml) and MCI (4450.0 ± 2592.0 pg/ml) compared to NHS (9172.2 ± 3984.8 pg/ml, p < 0.001), but significantly higher in AD (17,265.0 ± 7528.4 pg/ml) vs. NHS (p = 0.001).