Most of these variants are non-coding, save three missense mutations: rs3894194 and rs7212938 from GSDMA and rs2305480 from GSDMB. This study identified four additional coding variants from GSDMA (rs56030650), GSDMB (rs2305479, rs11078928) and ZPBP2 (rs11557467) and three eQTLs for ORMDL3 (rs12946510, rs11557466, rs8076131), which are in LD with asthma variants. The gene discussed is GSDMB; the disease is asthma.