The present study identified numerous LD variants within the same loci as these asthma variants including a splice-acceptor variant in the HLA-DRA gene (rs8084); missense variants in HLA-DQA1, HLA-DQB1, HLA-DRB, HLADRB5, and HLA-DPA1; and several eQTLs (rs204992, rs3131294, rs6928482, rs1063355, rs2076523, rs2213585) that are linked to the expression of one or more MHC class II genes. The gene discussed is HLA-DRB5; the disease is asthma.