Although, numerous indications in the literature highlight their role in the pathogenesis and progression of various tumors associated with the digestive system, in particular in hepatocellular carcinoma [8], and gastric tumors [23] our data do not suggest a fundamental role of HOX A13 and HOXD13 genes in colon cancer evolution. The gene discussed is HOXD13; the disease is malignant colon neoplasm.