In contrast, Mara et al. reported that TRIB2 might counteract the chemotherapy resistance and propagation in myeloid leukemia via activation of p38; in liver cancer, TRIB2 inhibits Wnt-signaling by regulating the degradation of key factors, such as βTrCP, COP1 and Smurf1 [6, 9]. The gene discussed is TRIB2; the disease is myeloid leukemia.