Several genes, such as TREX1, FLI1, EVI5, IL1RAPL1, are known for their role in autoimmunity, with EVI5 being an established MS risk gene (16), whereas others, such as CBFB, OPCML and KMT2A, are involved in lymphoproliferative disorders (OMIM). Here, IL1RAPL1 is linked to Autoimmunity.