FMO5 and Hypertension: It has been proposed that several possible underlying mechanisms of the role of oxidative stress in the pathophysiology of hypertension are increased reactive aldehyde, methylglyoxal, disrupted vascular calcium channels, enzymes, [45] oxidation of low-density lipoproteins, primarily by oxygen-free radicals [46], reduced bioactivity of NO and the activation of NAD(P)H oxidase in long term development of hypertension [47].