Recurring activation of insulin secretion due to dietary habits promotes insulin resistance.[42] Moreover abdominal obesity favors insulin resistance as a result of the effect of acute elevated FFA on skeletal muscle and glucose uptake in muscle.[43] Thus, it becomes obvious that pathomechanisms involved in the development of IR, dyslipidemia and obesity are closely intertwined and mutually reinforce and influence each other. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.