Recurring activation of insulin secretion due to dietary habits promotes insulin resistance.[42] Moreover abdominal obesity favors insulin resistance as a result of the effect of acute elevated FFA on skeletal muscle and glucose uptake in muscle.[43] Thus, it becomes obvious that pathomechanisms involved in the development of IR, dyslipidemia and obesity are closely intertwined and mutually reinforce and influence each other. Here, INS is linked to Obesity.