LIPC and Insulin resistance: Hypertriglyceridemia is one of the early and frequently detectable consequences of insulin resistance.[40] IR promotes the increase of free fatty acids (FFA), since insulin is involved in the inhibition of lipolysis in the liver with a subsequent increase in triglyceride levels.[41] Triglyceride-HDL particles can be easily degraded by the hepatic lipase in the liver, resulting in lower HDL-C levels.