NLRP5 and Adrenal insufficiency: Autoantibodies to 21-hydroxylase correlate with the development of adrenal insufficiency and antibodies to NALP5 correlate with the development of hypoparathyroidism and measuring these antibodies can be of value in predicting the development of adrenal insufficiency and hypoparathyroidism respectively A molecular diagnosis can be confirmed with DNA studies of the AIRE gene (14).