In addition to the previously mentioned role as a repressor of important negative regulators of liver fibrosis,11, 29 Xiao et al12 showed that inhibition of EZH2 also may reduce TGF-β–induced differentiation of human lung fibroblasts into myofibroblasts, preventing Smad2/3 nuclear translocation. This evidence concerns the gene SMAD2 and Hepatic fibrosis.