Finally, multiple evidences have shown that EZH2 is highly expressed and plays a key role in several types of cancer.9, 40, 41, 42 It has been identified as one of the most deregulated epigenetic modulators in hepatocellular carcinoma (HCC),10, 43 promoting hepatocarcinogenesis through different mechanisms. This evidence concerns the gene EZH2 and hepatocellular carcinoma.