This hypothesis has been suggested by Dalla Palma et al. [38], who showed that MM patients with high burden of osteolytic lesions recognized by PET/CT are mostly characterized by high amounts of BM concentrations of CCL3 (MIP1a) and CCL20 (MIP3a), whereas BM DKK-1 levels were mostly associated with the presence of focal lesions on MRI in MM patients. This evidence concerns the gene CCL3 and Miyoshi myopathy.