The use of biased agonists may be a valuable addition to the tools used to study the relative contribution of somatodendritic and post-synaptic 5-HT1A receptors in anxiety, since drugs like R(+)-8-OH-DPAT lack specificity for 5-HT1A receptor subpopulations and may diffuse to the raphe nuclei after infusion into forebrain regions hampering interpretation of results (Jolas et al. 1995). The gene discussed is HTR1A; the disease is Anxiety.