Systemic administration of F13714 or R(+)-8-OH-PDAT reduced vocalizations in the conditioned ultrasonic vocalization test (Remy et al. 1996; Assié et al. 2010), a response which is mediated through activation of somatodendritic 5-HT1A autoreceptors, at least in the case of R(+)-8-OH-DPAT (Remy et al. 1996), suggesting that systemic administration of these ligands may indeed reduce anxiety through activation of pre-synaptic 5-HT1A receptors. The gene discussed is HTR1A; the disease is Anxiety.