Prostatic hepcidin is regulated via interleukin 6 (IL6), similar to systemic (liver) hepcidin, but non-cannonical pathways, such as wingless/integrated (Wnt) pathway, sclerostin domain-containing protein 1 (SOSTDC1) and bone morphogenetic protein 4/7 (BMP4/7) are also responsible for PCa hepcidin expression, which suggests a differential control of hepcidin expression in PCa compared to liver hepcidin expression (47) (Table 1). This evidence concerns the gene HAMP and posterior cortical atrophy.