GNRH1 and Hypertension: Similar to the comparison of GnRH agonists and the antagonist, relative increases of hypertension and obstructive uropathy were significantly different between GnRH agonists and hybrids (Table 2): Regarding hypertension, the relative growth rate from index to follow-up period was significantly higher for GnRH agonists than for hybrids (p = 0.006).