They found no significant association between GnRH agonists and antagonists regarding myocardial infarction and ischemic stroke (adjusted HR 1.2, 95% CI [0.7–2.1]) Thus, Scailteux et al. concluded that the probability of a clinically meaningful difference comparing GnRH agonists and antagonists with regard to their effect on cardiovascular risk appears rather low (21). The gene discussed is GNRH1; the disease is ischemic stroke.