Significant differences between GnRH agonists and the GnRH antagonist were observed regarding the relative increase of hypertension and obstructive uropathy (Table 2): From index to follow-up period, the growth rate of hypertension was significantly higher in the GnRH agonist class compared to the antagonist (p = 0.022). This evidence concerns the gene GNRH1 and urinary tract obstruction.