High-resolution chromosomal microarray analysis identified this gain of copy number spanned 676 kb, involving almost the entire <i>NOX5</i> gene (except for exon 1 of the longer transcript), the entirety of the <i>EWSAT1</i>, <i>GLCE</i>, <i>PAQR5</i>, <i>KIF23</i>, <i>RPLP1</i>, and <i>DRAIC</i> genes and exons 1-3 of the <i>PCAT29</i> gene.<h4>Conclusion</h4>To date, this is the first report of an associated 15q23 gain in a case with omphalocele. The gene discussed is RPLP1; the disease is omphalocele.