Recently, antivascular endothelial growth factor (VEGF) therapy, including intravitreal ranibizumab (Lucentis), aflibercept (Eylea), and bevacizumab (Avastin), has become the option of first choice at home and abroad because the high level of VEGF may promote the retinal nonperfusion and ischemia [7]. This evidence concerns the gene VEGFA and ischemia.