ACTA1 and steatosis: In this study, the loss of c-Met on different liver cell types (Kupffer cells/macrophages, α-SMA+/CK19+ cells, and bone marrow-derived immune cells) led to severe steatosis, steatohepatitis, and fibrosis progression in two different mouse models of diet-induced steatohepatitis in all three used Cre lines (Figures 1, , , –5).