We here hypothesized that c-Met prevents from NASH-related fibrosis and wanted to clarify in detail on which cell type (LysCre for Kupffer cells/macrophages, GFAPCre for α-SMA+ and CK19+ cells, and MxCre for bone marrow-derived immune cells) c-Met is essentially involved in this process. This evidence concerns the gene ACTA1 and metabolic dysfunction-associated steatohepatitis.